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Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum lh, and causing the regression of estrogen-dependent tumors. Femara (generic name is letrozole) is an oral drug which can be an effective fertility treatment for women with ovulation problems, or for those with unexplained infertility. This medication is in a class of drug called aromatase inhibitors. Femara has mainly been used to treat certain cases of breast cancer. Letrozole is an oral non-steroidal aromatase inhibitor approved for the treatment of hormonally responsive breast cancer after surgery. It has been used (off-label) for ovulation induction as part of the ivf process since 2001. How do aromatase inhibitors work? Effectiveness of letrozole in extended adjuvant treatment of early breast cancer is based on an analysis of disease-free survival in patients treated for a median of 60 months. Dosage modifications renal impairment. Mild-to-moderate (crcl ≥30 ml/min): no dose adjustment necessary; severe (crcl ≥10 to ; 30 ml/min): no dose adjustment necessary. In another postapproval randomized, multicenter, open label, study of letrozole vs anastrozole in the adjuvant treatment of postmenopausal women with hormone receptor and node positive breast cancer (face, nct00248170), the median duration of treatment was 60 months for both treatment arms. Off-label use letrozole (letro) has many uses which have recently been discovered. Aside from its female breast cancer use (typical of all ai's), letro has off-label uses in medicine. Since 2001, the main off label usage has been as a fertility drug because of its ability to stimulate ovaries. Ribociclib plus letrozole versus chemotherapy for postmenopausal women with hormone receptor-positive, her2-negative, luminal b breast cancer (coralleen): an open-label, multicentre, randomised, phase 2 trial. Letrozole comes as a tablet to take by mouth once a day with or without food. Take letrozole at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take letrozole exactly as directed. A 2012 trial comparing letrozole alone to letrozole + palbociclib said the addition of palbociclib increased progression-free survival from 10. 2 months to 20. Fda-approves-palbociclib - rod57 17:39, 4 february 2015 (utc) external links modified. Hello fellow wikipedians, i have just modified one external link on letrozole. Medicare coverage and pricing details for letrozole. Learn more about medicare prescription drug plans and savings with goodrx. Letrozole, sold under the brand name femara among others, is an aromatase inhibitor which is used in the treatment of hormonally-responsive breast cancer after surgery. It was patented in 1986 and approved for medical use in 1996 
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